Journal article
Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL)
BR Cardoso, DJ Hare, AI Bush, QX Li, CJ Fowler, CL Masters, RN Martins, K Ganio, A Lothian, S Mukherjee, EA Kapp, BR Roberts
Journal of Alzheimer S Disease | IOS PRESS | Published : 2017
DOI: 10.3233/JAD-160622
Abstract
Selenium (Se) protects cells against oxidative stress damage through a range of bioactive selenoproteins. Increased oxidative stress is a prominent feature of Alzheimer's disease (AD), and previous studies have shown that Se deficiency is associated with age-related cognitive decline. In this study, we assessed Se status in different biofluids from a subgroup of participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. As Se in humans can either be an active component of selenoproteins or inactive via non-specific incorporation into other proteins, we used both size exclusion chromatography-inductively coupled plasma-mass spectrometry (SEC-ICP-MS) and tandem ..
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Awarded by Australian Research Council
Funding Acknowledgements
We would like to acknowledge the Australian Imaging and Biomarker, Lifestyle (AIBL) research team (a complete list of researchers can be found at http://www.aibl.csiro.au) and the volunteers and their families. We thank the Science without Borders (Ciencia sem Fronteiras) Fellowship that supported BRC research. The National Health and Medical Research Council. We acknowledge funding from the Victorian Government's Operational Infrastructure Support Program and the Australian Research Council Linkage Project Scheme (with Agilent Technologies; LP140100095). This project was supported in part by the National Health and Medical Research Council, the Cooperative Research Centre for Mental Health and The Florey Neuroproteomics Facility.